The oxycodone in OXYCONTIN may perhaps lead to spasm on the sphincter of Oddi. Opioids may trigger improves inside the serum amylase. Routinely evaluate patients with biliary tract disorder, which include acute pancreatitis, for worsening symptoms.The concomitant utilization of OXYCONTIN and CYP3A4 inhibitors can raise the plasma focus of oxycodone